Protein domains/Linker

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Linkers are short peptide sequences that occur between protein domains. Linkers are often composed of flexible residues like glycine and serine so that the adjacent protein domains are free to move relative to one another. Longer linkers are used when it is necessary to ensure that two adjacent domains do not sterically interfere with one another.


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NameDescriptionAA sequenceLength
BBa_J176131PLrigid 60
BBa_J189202aa GS linker  6
BBa_J189216aa [GS]x linker  18
BBa_J1892210aa [GS]x linker 30
BBa_K10501210 aa flexible protein domain linker  30
BBa_K1331328 aa protein domain linker 24
BBa_K1486003Flexible linker 2x (GGGS) 24
BBa_K1486004flexible linker 2x (GGGGS) 30
BBa_K148603713 amino acids linker [GGGS GGGGS GGGS] 39
BBa_K148605310 aa linker 30
BBa_K157009Split fluorophore linker; Freiburg standard 51
BBa_K15701315 aa flexible glycine-serine protein domain linker; Freiburg standard 45
BBa_K1680001protein linker, 9aa 15
BBa_K1680002Protein linker, 12aa 24
BBa_K1680003Protein linker, 15 amino acids 33
BBa_K1777005flexible linker with SV40 NLS 124
BBa_K1777019flexible linker 36
BBa_K2355001Cleavable peptide linker for Bitis arietans and Bitis gabonica venom 72
BBa_K2382004Thioredoxin with polylinker 384
BBa_K2429126Glycine-Serine Linker 24
BBa_K243004Short Linker (Gly-Gly-Ser-Gly) 12
BBa_K243005Middle Linker ( Gly-Gly-Ser-Gly)x2 24
BBa_K243006Long Linker (Gly-Gly-Ser-Gly)x3 36
BBa_K243029GSAT Linker 108
BBa_K243030SEG 108
BBa_K2549045linker between GAL4 DNA binding domain and VP64 transcription activator 36
BBa_K2549053G4S linker 15
BBa_K2812004Coding sequence for trunctated Lysostaphin fused to His-tagged HlyA 1458
BBa_K2812005Coding sequence for trunctated Lysostaphin with HlyA and His6-tag regulated by T7-promoter 1496
BBa_K2812006Coding sequence for Pyocin S5 with HlyA and His6-tag 2217
BBa_K2812007Coding sequence for Pyocin S5 with HlyA and His6-tag regulated by pBAD-ara promoter 2288
BBa_K3120002Glycine linker 12
BBa_K3672000(HL5)2 peptide helical linker, rigid;separate the domains of fusion proteins 89
BBa_K3765005Glycine-Serine linker (GSGGS) 15
BBa_K3765006Glycine-Serine linker (GSSGS) 15
BBa_K376500922 Amino Acid Linker  66
BBa_K3790007(G2S)3 27
BBa_K404300SEG-Linker 108
BBa_K404301GSAT-Linker 108
BBa_K404303Z-EGFR-1907_Short-Linker  192
BBa_K404304Z-EGFR-1907_Middle-Linker  204
BBa_K404305Z-EGFR-1907_Long-Linker  216
BBa_K404306Z-EGFR-1907_SEG-Linker  288
BBa_K416001(Gly4Ser)3 Flexible Peptide Linker 45
BBa_K4189000linker 24
BBa_K419000410aa GS Linker (E. coli) 30
BBa_K419000510aa GS Linker (S. cerevisiae) 30
BBa_K4359003(SSSSG)x2 serine glycine linker 30
BBa_K4422005Short Flexible Linker Gly-Gly-Ser-Gly (Pichia pastoris codon optimized) 12
BBa_K4765017linker after INPNC 48
BBa_K5271006Linker 36
BBa_K5466003Flexible linker 3x(GGGGS) Saccharomyces cerevisiae codon optimized 45
BBa_K5490010GS10 LINKER 30
BBa_K648005Short Fusion Protein Linker: GGSG with standard 25 prefix/suffix 12
BBa_K648006Long 10AA Fusion Protein Linker with Standard 25 Prefix/Suffix 30
BBa_K648007Medium 6AA Fusion Protein Linker: GGSGGS with Standard 25 Prefix/Suffix 18


References

<biblio>

  1. Argos pmid=2313701
  2. Crasto pmid=10835103
  3. George pmid=12538906
  4. Arai pmid=11579220

</biblio>