Signalling

Part:BBa_K5036008

Designed by: Emad hamdy Matter   Group: iGEM24_AFCM-Egypt   (2024-09-12)
Revision as of 10:27, 12 September 2024 by Em100 (Talk | contribs) (→‎Usage)


NES

Part Description

It is a Nuclear Export Signal which is a short sequence of amino acids found in certain proteins that direct those proteins out of the nucleus of a cell. . In our model it is engineered in our second chain of the receptor

Usage

It help in increasing control over transcription activity by preventing delivery of dCas9 into the nucleus without activation of our syn dCas9RTK receptor

this figure illustrates the structure of NES in the second chain of syn dCas9RTK receptor .

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None