Coding

Part:BBa_K3712002

Designed by: Sheng Wang   Group: iGEM21_HUST2-China   (2021-10-19)
Revision as of 01:41, 20 October 2021 by Registry (Talk | contribs)

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Optimized BLP-7

Although, BLP-7 has a huge power against bacteria, its antibacterial and anti-inflammatory effects are still able to be further improved. Theoretically, increasing the net positive charge and hydrophobicity of antimicrobial peptides can improve its antibacterial ability. In this project, we carried out amino acid mutation of wild-type BLP-7 through modeling design, replaced specific amino acids to improve its hydrophobicity, so that antimicrobial peptides could better bind to bacterial cell membranes and improve its drilling ability. In this way, we expect to obtain a more stable mutant BLP-7 with better antibacterial and anti-inflammatory effects.

Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal PstI site found at 26
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal PstI site found at 26
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal PstI site found at 26
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal PstI site found at 26
  • 1000
    COMPATIBLE WITH RFC[1000]


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Parameters
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