Help:Regulatory

Revision as of 16:54, 7 July 2006 by Smelissali (Talk | contribs) (→‎Constitutive parts)

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Regulatory parts are those which provide binding regions for RNA polymerase, the enzyme which performs the act of transcription (the conversion of DNA to RNA).

Some sub-categories of Regulatory parts are:

Constitutive parts

Parts which allow for continual transcription of parts. Often these parts can be de-activated (transcription downregulated) by the addition of ligand. The use of constituitive promoters can be desirable since they are less susceptible to cross-talk and can hypothetically take in PoPS input.

Examples of constitutive parts include

  • Part:BBa_R0040 - the pTet promoter region, controlled by tetracycline or its chemical analog [http://openwetware.org/wiki/ATc ATC]
  • Part:BBa_R0010 - the pLac promoter region, controlled by the lactose protein or by its chemical analog [http://openwetware.org/wiki/IPTG IPTG]
  • Part:BBa_R0051 - the pR bacteriophage lambda promoter region, controlled by the presence of the cI protein

Inducible parts

Parts which are continually "off" (transcription is not induced), but allow for activation (increase transcription) through the addition of particular chemicals
Examples include:

  • Part:BBa_R0080 - The araC promoter region, which can be activated by the addition of the sugar [http://openwetware.org/wiki/Arabinose arabinose]
  • Part:BBa_I0500 - Another [http://openwetware.org/wiki/Arabinose arabinose] inducible promoter region