Coding

Part:BBa_K5499005

Designed by: Hongjing Wang   Group: iGEM24_NWU-CHINA-A   (2024-09-29)
Revision as of 19:43, 29 September 2024 by Registry (Talk | contribs)

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LAMP2A signal peptide

The signal peptide of LAMP2A is a short amino acid sequence (typically around 15-30 residues) that serves as a molecular "address" that directs the protein to the secretory pathway. Here are key roles the LAMP2A signal peptide plays: Translocation to the ER: The signal peptide facilitates the translocation of the LAMP2A precursor protein into the lumen of the ER. This is essential for proper folding and modification (e.g., glycosylation). Membrane Integration: After processing in the ER, the signal peptide is cleaved off, and the mature LAMP2A protein is integrated into the lysosomal membrane, where it can perform its functions.

If you are interested in exosome-based drug delivery, incorporating the LAMP2A signal peptide can help direct proteins into exosomes. This can increase the efficiency of exosome production and enhance the therapeutic potential of exosome-mediated delivery systems.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None