Part:BBa_K5499005
LAMP2A signal peptide
The signal peptide of LAMP2A is a short amino acid sequence (typically around 15-30 residues) that serves as a molecular "address" that directs the protein to the secretory pathway.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Profile
Name: LAMP2A Signal Peptide
Base Pairs: 84 bp
Origins: Derived from the lysosomal-associated membrane protein 2 (LAMP2) gene, commonly found in mammals.
Properties: It selectively recognizes cytosolic proteins containing specific amino acid sequences, such as the KFERQ motif, which are essential for their translocation into exosomes.
Usage and Biology
The LAMP2A signal peptide is commonly utilized in synthetic biology and genetic engineering to direct protein localization to exosomes. By attaching this signal peptide to the N-terminus of recombinant proteins, researchers can ensure the correct localization of intracellular proteins on the exosomal membrane, which is crucial for the functionality of exosomes and proteins.
This precise targeting is particularly important in therapeutic applications, where exosomes serve as natural vehicles for drug delivery and intercellular communication.
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