Composite
Part:BBa_K3733042
Designed by: Zhenhao Han Group: iGEM21_HZAU-China (2021-10-01)
Revision as of 16:26, 18 October 2021 by HanZhenhao (Talk | contribs)
PhoA-azurin with a His-tag
Azurin is a copper-containing redox protein secreted by Pseudomonas aeruginosa. Azurin preferentially enters a variety of cancer cells and induces apoptosis or cell cycle arrest, thereby playing an anti-cancer effect. A 6×His tag was added in order to purify the protein. PhoA, a signal peptide of Sec pathway in Escherichia coli, have the capability to guide the LL-37 excrete out of the cell.
Reference
Huang F, Qianhui S, Zhaojie Q, et al. Anticancer actions of azurin and its derived peptide p28[J]. The protein journal, 2020, 39(2): 182-189.
[edit]
Categories
Parameters
| None |