RNA

Part:BBa_K2923002:Design

Designed by: claire husser   Group: iGEM19_Strasbourg   (2019-09-12)
Revision as of 09:34, 13 October 2019 by Katya (Talk | contribs)

aptazyme theophylline inactif


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

=Aptazyme is composed of three different part : =Theo5 as a communication module, =P1 as a twister ribozyme mutated in the 14 an 15 position to inhibit the RNA cleavage activity of the ribozyme part =Aptamer module specific to theophylline.



Source

Felletti, M., Stifel, J., Wurmthaler, L.A., Geiger, S., and Hartig, J.S. (2016). Twister ribozymes as highly versatile expression platforms for artificial riboswitches. Nature Communications 7