Protein_Domain

Part:BBa_K4175005

Designed by: Li Xianxiu, Zhang Wanying   Group: iGEM22_ZJUintl-China   (2022-08-28)


CD8 transmembrane domain

Together with CD8 hinge domain (BBa_K4175004), this part is used to connect anti-CD19 single chain variable fragment (scFv) with intracellular signalling motifs (e.g., 4-1BB and CD3ζ in the second-generation CAR). In our project, this basic part is used in the composite part, anti-CD19 CAR (BBa_K4175012).

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal NgoMIV site found at 34
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
biologyHuman