Pep8 is an artificial peptide that was shown to play a potential role in the re-induction of p53 translation which leads to decreased tumor growth in mice xenograft.1 p53 acts as tumor suppressor by preserving the integrity of the genome. p53 loss of function is associated with more than half of all human cancers.2,3 Further, Pep8 was shown to sensitize cancer cells to an anticancer drug doxorubicin.1 Pep8 is part of the composite parts BBa_K3861024 and BBa_K3861026.
Sequence and Features
- 10COMPATIBLE WITH RFC
- 12COMPATIBLE WITH RFC
- 21COMPATIBLE WITH RFC
- 23COMPATIBLE WITH RFC
- 25COMPATIBLE WITH RFC
- 1000COMPATIBLE WITH RFC
1. Lucchesi, C. A., Zhang, J., Ma, B., Chen, M. & Chen, X. Disruption of the Rbm38-eIF4E Complex with a Synthetic Peptide Pep8 Increases p53 Expression. Cancer Res. 79, 807–818 (2019).
2. Vogelstein, B., Lane, D. & Levine, A. J. Surfing the p53 network. Nature 408, 307–310 (2000).
3. Vousden, K. H. & Prives, C. Blinded by the Light: The Growing Complexity of p53. Cell 137, 413–431 (2009).