Part:BBa_K4693001
Gsalpha
The Gs alpha subunit is a part of the heteromeric G protein family Gs that activates the adenylyl cyclase in the cAMP-dependent pathways. The cAMP-dependent pathways is a signaling cascade involved in cell communication. The Gs alpha is from the GTPases family, which functions as a cellular signaling protein. Of the four families of heteromeric G protein, Gs alpha is one of its founding members and it is characterized by the alpha subunit. In humans, Gs alpha is coded by the GNAS (Guanine Nucleotide Binding Protein) complex locus. Gs alpha is a unique biomarker that has just been discovered for its relationship to major depressive disorder (MDD). Gs alpha is often dispersed between a specialised part of the membrane rich in cholesterol (lipid raft) and non-raft portions of the membrane, where it may move about freely and facilitate neurotransmitter-activated adenylyl cyclase activity. However, in people with MDD, the Gs alpha protein is sequestered in the lipid raft and is attached by the structural protein tubulin. This inhibits the adenylyl cyclase pathways activity, which causes it to be downregulated in people with MDD.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BamHI site found at 1202
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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