Coding

Part:BBa_K2562001

Designed by: Marina Takehana   Group: iGEM18_ASIJ_Tokyo   (2018-09-30)


E342K point mutation in SERPINA1 gene

The SERPINA1 gene coding for the Alpha-1 Antitrypsin protein is derived from Homo sapiens. The coding sequence has a point mutation at E342K, a replacement of glutamic acid for lysine. The mutation accounts for Alpha-1 antitrypsin deficiency, in which the lack of Alpha-1 antitrypsin leads to a defective lung and liver.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal XhoI site found at 169
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
//awards/basic_part
Parameters
None