RNA

Part:BBa_K1860700

Designed by: Maurice Langhinrichs, Vincent Fortuin, Henning Jacobsen   Group: iGEM15_Hamburg   (2015-09-13)

miRNA2911

Lonicera japonica or the Japanese honeysuckle plant is a well-known Chinese herb and has been used to effectively treat influenza infection for thousands of years. The group around Zhou found that the major portion of detected miRNAs in this plant are being degraded by boiling and only miRNA2911 stayed resistant and active in a decoction. Throughout a bioinformatival prediction and luciferase reporter assays they showed that miRNA2911 has antiviral properties by targeting various Influenza A viruses (IAV); e.g. H1N1, H5N1, H7N9. miRNA2911 is highly stable because of its folding and elevated levels could be detected in peripheral blood and lung tissues of mice after gavage feeding of the honeysuckle decoction.

We validated the miRNA2911 BioBrick by sequencing and submitted it to the registry. Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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