Signalling

Part:BBa_M41016

Designed by: Laila Shehata   Group: MIT BE 20.20-S13   (2013-05-14)


Calcium sensor from Streptococcus mutans

CiaH is a histidine kinase calcium sensor from gram-positive bacteria Streptococcus mutans. CiaH works in conjunction with CiaX (an extracellular calcium-binding peptide) and CiaR (an intracellular reporting molecule that acts as an activator) to control expression of the cia operon. When extracellular calcium concentrations are low, CiaH (activated by unbound CiaX) phosphorylates CiaR, enabling CiaR to act as an activator for the cia operon. Explanation of cia operon: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955730/

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
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  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None