Part:BBa_K5452132

Erg20

This part codes for ERG20 enzyme, responsible for the conversion of IPP to geranyl diphosphate (GPP) then into farnesyl diphosphate (FPP) in the Monoterpenoid metabolic pathway in Saccharomyces cerevisiae

Usage and Biology

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]

The ERG20 enzyme functions in the monoterpenoid pathway in S. cerevisiae and plays a dual role: it converts IPP into GPP, and then GPP into FPP. GPP, resulting from the condensation of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), is recognized as the last common precursor of monoterpenes, as both IPP and DMAPP are synthesized via the mevalonate pathway, which is also present in yeast. Through the metabolic engineering employed in this project, we can better understand the branching of this pathway towards a synthetic route, as well as the role of enzyme repression in yeast metabolism.