Part:BBa_K524100

Bcr - multidrug efflux system

Bcr is a multidrug efflux pump that belongs to the major facilitator superfamily (MFS), native to Escherichia coli. When overexpressed in E. coli, it is known to confer varying degrees of resistance to several antibiotics, including bicyclomycin (selection-capable); tetracycline (8-fold increase in MIC^); kanamycin (4-fold increase in MIC^); fosfomycin (4-fold increase in MIC^); and acriflavine (2-fold increase in MIC^) [see Reference 2].

^: Compared with wild type

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  INCOMPATIBLE WITH RFC[21]

  Illegal BamHI site found at 503
  
• 23
  COMPATIBLE WITH RFC[23]
• 25
  INCOMPATIBLE WITH RFC[25]

  Illegal AgeI site found at 99
  
• 1000
  COMPATIBLE WITH RFC[1000]