Part:BBa_K4829012
Membrane receptor CD36
This DNA sequence codes for the membrane receptor CD36. Scavenger receptor B3 (SR-B3), also known as CD36.
Usage and Biology
CD36 (or SR-B3) is a cell surface receptor expressed on macrophages, among other cell types. It belongs to the class B scavenger receptor family and is crucial in lipid metabolism and immune responses; SR-B3 on macrophages functions as a multifunctional receptor involved in recognising, binding, and internalising a wide range of ligands, including modified lipoproteins, apoptotic cells, microbial pathogens, and various fatty acids. By mediating the uptake of these diverse ligands, SR-B3 contributes to the clearance of apoptotic cells and cellular debris, regulating lipid homeostasis and modulating inflammatory responses. Clearly, SR-B3 on macrophages play a pivotal role in immune responses. What is more important in our context, however, is that macrophages appear to lose their phagocytic ability when CD36 is downregulated. This has been proposed to occur because of higher concentrations of PGE2 in the peritoneal fluid of women with endometriosis (which has been shown to exist). Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12INCOMPATIBLE WITH RFC[12]Illegal NheI site found at 433
- 21INCOMPATIBLE WITH RFC[21]Illegal BamHI site found at 71
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal AgeI site found at 1255
- 1000COMPATIBLE WITH RFC[1000]
Functional Parameters
We have not tested out this construct, nor could we find any literature where it has been published.
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