Coding

Part:BBa_K4739012

Designed by: Huaiyuan Ma   Group: iGEM23_SUSTech-Shenzhen   (2023-10-11)


Tenecteplase, a myocardial peptide drug

Tenecteplase, a thrombolytic agent produced using recombinant DNA technology, is FDA-approved for reducing mortality in ST-elevation acute myocardial infarction (STEMI) patients. It is also used off-label for treating acute ischemic stroke, pulmonary embolism, and clearing central venous catheters. Despite not being FDA-approved for acute ischemic strokes, its use is growing due to advantages like a single-dose intravenous administration and lower cost compared to alteplase. Particularly for stroke treatment, tenecteplase is a more cost-effective option than alteplase in the US market, saving approximately $3000 per dosage.

Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal EcoRI site found at 615
    Illegal EcoRI site found at 1087
    Illegal PstI site found at 1204
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal EcoRI site found at 615
    Illegal EcoRI site found at 1087
    Illegal PstI site found at 1204
    Illegal NotI site found at 886
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal EcoRI site found at 615
    Illegal EcoRI site found at 1087
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal EcoRI site found at 615
    Illegal EcoRI site found at 1087
    Illegal PstI site found at 1204
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal EcoRI site found at 615
    Illegal EcoRI site found at 1087
    Illegal PstI site found at 1204
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None