Part:BBa_K4739010
Parkin, an E3 ubiquitin ligase regulating mitochondrial biology
Parkin is an E3 ubiquitin ligase that manages the metabolism of mitochondria. Over the past twenty years, Parkin has been recognized not only for regulating mitochondrial removal but also for managing its biogenesis, dynamics, and vesicle formation, thereby maintaining mitochondrial health. Although primarily identified as a cytosolic enzyme, Parkin also functions in other cellular regions like the nucleus, influencing transcription factors and acting as one itself. Intriguingly, overexpressing Parkin has shown potential anti-aging effects; in Drosophila, it extends lifespan, while in mammals, it delays aging markers in various tissues and cells, providing protection in models of cellular senescence and age-related neurological disorders like Alzheimer's and Parkinson's diseases. Recent findings also indicate Parkin’s capability to suppress tumor growth.
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal PstI site found at 614
Illegal PstI site found at 973 - 12INCOMPATIBLE WITH RFC[12]Illegal PstI site found at 614
Illegal PstI site found at 973 - 21COMPATIBLE WITH RFC[21]
- 23INCOMPATIBLE WITH RFC[23]Illegal PstI site found at 614
Illegal PstI site found at 973 - 25INCOMPATIBLE WITH RFC[25]Illegal PstI site found at 614
Illegal PstI site found at 973
Illegal NgoMIV site found at 396
Illegal AgeI site found at 247 - 1000COMPATIBLE WITH RFC[1000]
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