Part:BBa_K4636002

cDNA of 0004771

We discovered that the expression level of a circRNA, known as hsa_circ_0004771, exhibits a significant increase in the bloodstream of early-stage colorectal cancer patients.

Main

Circular RNA (circRNA) is a type of single-stranded, covalently closed RNA. (Figure 1) In recent years, it has emerged as a focal point in the non-coding RNA field. Additionally, many circRNAs have been identified as promising diagnostic biomarkers because of their stable circular structure, which prevents degradation, and their abnormal expression in certain diseases.[1]

Figure 1. Comparison of CircRNA and Linear RNA.

After conducting extensive paper research, we discovered that the expression level of a circRNA, known as hsa_circ_0004771, exhibits a significant increase in the bloodstream of early-stage colorectal cancer patients. Moreover, it demonstrates high specificity and sensitivity.[2] Therefore, hsa_circ_0004771 holds the potential to serve as a valuable biomarker for diagnosis. In pursuit of this goal, we have registered a complementary DNA sequence for hsa_circ_0004771.

Design

We found the sequence in circBank and copied it.[3]

Reference

1. Liu, X., Zhang, Y., Zhou, S., Dain, L., Mei, L., & Zhu, G. (2022). Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines. *Journal of controlled release : official journal of the Controlled Release Society*, *348*, 84–94. https://doi.org/10.1016/j.jconrel.2022.05.043
2. Pan, B., Qin, J., Liu, X., He, B., Wang, X., Pan, Y., Sun, H., Xu, T., Xu, M., Chen, X., Xu, X., Zeng, K., Sun, L., & Wang, S. (2019). Identification of Serum Exosomal hsa-circ-0004771 as a Novel Diagnostic Biomarker of Colorectal Cancer. *Frontiers in genetics*, *10*, 1096. https://doi.org/10.3389/fgene.2019.01096
3. http://www.circbank.cn/search.html?selectValue=hsa_circ_0004771