Part:BBa_K4578000

Salp12

Salp12 is a protein found in the salivary glands and midgut of the Ixodes scapularis tick, the main host of the Borrelia burgdorferi spirochete and causative agent of Lyme Disease. The protein has been found to function as a chemoattractant for B. burgdorferi, playing a role in the acquisition of the spirochete into new tick hosts from infected prey. Salp12 can be used in projects as a initiate B. burgdorferi chemotaxis. This is a new addition to the iGEM Parts Registry with the hope of spurring on additional synthetic biology research to combat Lyme disease caused by B. burgdorferi.

This part comes from the salivary glands and midgut of the Ixodes scapularis tick.

The amino acid sequence of Salp12 was found in the supplemental data for the 2019 paper published by Murfin et al. and reverse translated, codon optimized for E. coli.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]