Part:BBa_K4496001

This part is a Jararhagin, a highly hemorrhagic class P-III SVMP (metalloprotease) from Bothrops Jararaca venom. It has a molecular mass of 52 kDa, which is considered high. In the catalytic domain is the zinc-binding sequence HEXXHXXGXXH and the Met-turn structure, which helps stabilize the three histidine residues involved in catalysis (Bode et al., 1993; Stöcker et al., 1995). In the disintegrin domain there is conservation of the cysteine residues in the same position as those found in RGD, but with replacement by an ECD sequence, common to other P-III SVMPS. That is, it has the disintegrin-like domain (BJARNASON; FOX, 1995). The cysteine-rich disintegrin domains have high similarities with the domains found in ADAMs (Paine et. al., 1992).