Part:BBa_K4458014
Cytochrome P450 Family 1 Subfamily A Member 1(CYP1A1)
"This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]"
https://www.ncbi.nlm.nih.gov/gene/1543
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal XbaI site found at 1426
Illegal XbaI site found at 3411
Illegal PstI site found at 944
Illegal PstI site found at 1021 - 12INCOMPATIBLE WITH RFC[12]Illegal NheI site found at 2620
Illegal PstI site found at 944
Illegal PstI site found at 1021 - 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 670
Illegal BglII site found at 721
Illegal BglII site found at 1111
Illegal BamHI site found at 697 - 23INCOMPATIBLE WITH RFC[23]Illegal XbaI site found at 1426
Illegal XbaI site found at 3411
Illegal PstI site found at 944
Illegal PstI site found at 1021 - 25INCOMPATIBLE WITH RFC[25]Illegal XbaI site found at 1426
Illegal XbaI site found at 3411
Illegal PstI site found at 944
Illegal PstI site found at 1021
Illegal NgoMIV site found at 2634 - 1000INCOMPATIBLE WITH RFC[1000]Illegal BsaI site found at 1844
Illegal BsaI.rc site found at 266
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