Coding

Part:BBa_K4458011

Designed by: Maya Balakumaran   Group: iGEM22_East_Coast_BioCrew   (2022-10-01)


Aryl Hydrocarbon Receptor Nuclear Translocator(ARNT)

"This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]"

https://www.ncbi.nlm.nih.gov/gene/405

Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal EcoRI site found at 346
    Illegal XbaI site found at 1854
    Illegal SpeI site found at 1303
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal EcoRI site found at 346
    Illegal NheI site found at 151
    Illegal SpeI site found at 1303
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal EcoRI site found at 346
    Illegal BamHI site found at 1272
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal EcoRI site found at 346
    Illegal XbaI site found at 1854
    Illegal SpeI site found at 1303
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal EcoRI site found at 346
    Illegal XbaI site found at 1854
    Illegal SpeI site found at 1303
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI site found at 583
    Illegal BsaI.rc site found at 119
    Illegal BsaI.rc site found at 1149


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