Part:BBa_K4422006

Omega-hexatoxin-Hv2a (AcTx-Hv2a)

ω-Hexatoxin-Hv2a (ω-HXTX-Hv2a or AcTx-Hv2) from the Australian spider Hadronyche versuta, is a specific and potent blocker of voltage-gated calcium channels. It is a 45 amino acid peptide containing a compact disulfide-rich core, including a highly hydrophobic C-terminal tail that is essential for interaction with insect calcium channels, the three disulfide bridges in the hydrophobic core form a binding motif inhibitory cysteine.

Wang, X. H., Connor, M., Wilson, D., Wilson, H. I., Nicholson, G. M., Smith, R., Shaw, D., Mackay, J. P., Alewood, P. F., Christie, M. J., & King, G. F. (2001, October). Discovery and Structure of a Potent and Highly Specific Blocker of Insect Calcium Channels. Journal of Biological Chemistry, 276(43), 40306–40312. https://doi.org/10.1074/jbc.m105206200.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]