Part:BBa_K4397002
Amyloid-Beta Aptamer: T-SO508
Amyloid Beta Aptamer
Target: oligomers of αSyn and Aβ40 oligomer
Binding Affinity: 25 nM (ELONA)
Usage and Biology
T-SO508 is a DNA aptamer specific for Aβ oligomer, suggesting that the G-quadruplex form of DNA aptamer tends to preferentially bind to the β-structures of Aβ oligomer [1]. Presently, aptamer T-SO508 has been the most commonly used recognition molecule in Aβ40 oligomers detection [1]. T-SO508 is suitable for the construction of Aβ sensing platforms, however the distinction between Aβ40 oligomer and Aβ42 oligomer is limited [1]. T-SO508’s high affinity for Aβ is beneficial to improve detection sensitivity and inhibition efficiency for further applications in clinical diagnosis and treatment of AD. However, compared to α-synuclein oligomers, affinity of T-SO508 aptamer to Aβ40 oligomers was slightly lower (Kd value of 25nM) [1].
[1] Zheng, Y., Zhang, L., Zhao, J., Li, L., Wang, M., Gao, P., ... & Wang, W. (2022). Advances in aptamers against Aβ and applications in Aβ detection and regulation for Alzheimer's disease. Theranostics, 12(5), 2095.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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