Part:BBa_K4211002

Secreted peptide: IL-2 signal sequence

The IL-2 Signal sequence is a secreted peptide sequence. Homo sapiens interleukin-2 mRNA (partial cds) is a member of the interleukin 2 (IL-2) cytokine subfamily which includes IL-4, IL-7, IL-9, IL-15, IL-21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. The IL-2 Signal sequence is the sequence of bases 13-69 on IL-2, which has the function of secreting IL-2 out of the cell.

Usage and Biology

We used IL-2 signal sequence to promote the secretion of LL-37, bFGF, Cex, CenA, Bglx proteins into the extracellular.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]