Part:BBa_K4173022

CD63

CD63 is a member of the tetraspanin superfamily of activation-linked cell surface antigens with N-terminal and C-terminal intracellular domains, two link domains and two annular extracellular domains, and is one of the most widely used exosome markers(CD63, CD9, CD81). More recently, however, their presence in other EVs has been observed. According to the latest study, CD63 was proved to be the specific marker for exosome, while EVs bearing only CD9 or CD81 but not CD63 probably did not form in endosomes. CD63 is known for its abnormally high levels on the surface of activated basophils, on proliferating mast cells, and on the surface of endothelial cells in inflamed tissue. CD63 plays an important role in the regulation of cargo sorting and vesicle formation. As a transmembrane protein located specifically on exosomes, it can be used as a base protein for fusing other proteins on which help the target protein locate on the membrane and be packaged into exosomes.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]