Part:BBa_K4173021
beta catenin
The gene not only encodes classical calcium mucin adhesion complex which is not only an important composition of the cytoplasm that formed in the epithelial cells of the adhesive connection but also mediates cell-cell adhesion of many other organizations, encodes Wnt signaling pathways in the typical key signaling molecule which is the signaling pathways in normal development to control in the process of tumor cell growth and differentiation. The gene product contains a central armadillo repeat domain through which it binds to the cytoplasmic tail of classical cadherins. At the same time, it also binds α-catenin, further linking the cadherin complex directly or indirectly to the actin cytoskeleton. So β-catenin is necessary for the adhesion of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. If there is an absence of of Wnt signaling, cytoplasm-serial protein which has nothing to do with the calcium mucin complexes serine/threonine residues on the n end on the degradation of so-called complex is fast phosphorylated. The degradation of protein complexes containing axis, adenomatous escherichia coli (APC), casein kinase I and GSK3B might play, and this complexes then go through TRCP ubiquitin and proteasome degradation. However, in the presence of Wnt signaling, the degradation complex is disrupted and stable cytoplasmic -catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations in this gene have been linked to various types of tumors. Splice variants of the gene have also been found.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12INCOMPATIBLE WITH RFC[12]Illegal NotI site found at 72
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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