Protein_Domain

Part:BBa_K4040036

Designed by: Tong Yin   Group: iGEM21_NMU_China   (2021-09-29)


CD20

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal NgoMIV site found at 220
    Illegal NgoMIV site found at 625
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI.rc site found at 751
    Illegal BsaI.rc site found at 820
    Illegal BsaI.rc site found at 826

Usage and Biology

It is a B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes[1]. CD40 Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR[2].

References

[1]Tedder TF, Boyd AW, Freedman AS, Nadler LM, Schlossman SF. The B cell surface molecule B1 is functionally linked with B cell activation and differentiation. J Immunol. 1985 Aug;135(2):973-9. PMID: 3925015.

[2]Bubien JK, Zhou LJ, Bell PD, Frizzell RA, Tedder TF. Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. J Cell Biol. 1993 Jun;121(5):1121-32. doi: 10.1083/jcb.121.5.1121. PMID: 7684739; PMCID: PMC2119683.



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