RNA

Part:BBa_K3840069

Designed by: Nefeli Zikou   Group: iGEM21_Greece_United   (2021-10-01)


mir-140

MicroRNA 140 is a microRNA overexpressed during the differentiation of Chondrocytes. In osteoarthritic cartilage the expression of miR-140 is reduced in comparison to healthy cartilage. Target genes of miR-140 include ADAMTS5 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif 5), MMP13 (Matrix Metalloproteinase 13), IGFBP5 (Insulin Like Growth Factor Binding Protein 5) and RALA (RAS like proto-oncogene A).

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal XhoI site found at 117
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI.rc site found at 120


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Categories
Parameters
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