Part:BBa_K380010
Immunoglobulin G protease (IdeS)
Immunoglobulin G protease (IdeS) is a proteolytic enzyme produced by Streptococcus pyogenes. The protein is designated to IdeS for Immunoglobulin G-degrading enzyme of S. pyogenes. This streptococcal cysteine proteinase, IdeS, is an immunoglobulin-degrading enzyme. It has a high specificity to cleave human IgG antibodies at the hinge region.
Reference:
- IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G. von Pawel-Rammingen U et al. EMBO J. 2002 Apr 2;21(7):1607-15.
- IdeS and SpeB: immunoglobulin-degrading cysteine proteinases of Streptococcus pyogenes. von Pawel-Rammingen U et al. Curr Opin Microbiol. 2003 Feb;6(1):50-5.
Immunoglobulin G protease (IdeS): Protein name: IgG-degrading protease.
Molecular function: Protease
Protein existence: Evidence at protein level. http://www.uniprot.org/uniprot/Q7DAM2. The identification, purification and characterization of IgG protease (IdeS) was first done by IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G. von Pawel-Rammingen U et al. EMBO J. 2002 Apr 2;21(7):1607-15.
Our iGEM group recived this gene from http://www.umu.se/sok/english/staff-directory/view-person?uid=ulvo0001.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000INCOMPATIBLE WITH RFC[1000]Illegal SapI.rc site found at 268
MIT MAHE 2020
Summary
Immunoglobulin G protease (IdeS) is a proteolytic enzyme produced by Streptococcus pyogenes. The protein is designated to IdeS for Immunoglobulin G-degrading enzyme of S. pyogenes. This streptococcal cysteine proteinase, IdeS, is an immunoglobulin-degrading enzyme. It has a high specificity to cleave human IgG antibodies at the hinge region.
References
1. Johansson, B. P., Shannon, O., & Björck, L. (2008). IdeS: a bacterial proteolytic enzyme with therapeutic potential. PloS one, 3(2), e1692. https://doi.org/10.1371/journal.pone.0001692
2. Woodle, E. S., Tremblay, S., & Driscoll, J. J. (2017). IgG Endopeptidase in Highly Sensitized Patients Undergoing Transplantation. The New England journal of medicine, 377(17), 1692–1693. https://doi.org/10.1056/NEJMc1711335
3. Nandakumar, K. S., Johansson, B. P., Björck, L., & Holmdahl, R. (2007). Blocking of experimental arthritis by cleavage of IgG antibodies in vivo. Arthritis and rheumatism, 56(10), 3253–3260. https://doi.org/10.1002/art.22930
4. Scully, M., Hunt, B. J., Benjamin, S., Liesner, R., Rose, P., Peyvandi, F., Cheung, B., Machin, S. J., & British Committee for Standards in Haematology (2012). Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. British journal of haematology, 158(3), 323–335. https://doi.org/10.1111/j.1365-2141.2012.09167.x
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