Part:BBa_K3721920
Alkali inducible promoter-Bacillus subtilis
This promoter sequence is recognized by a sigma factor sigma W. The SigmaW transcription factor is a stress factor induced in conditions of antibiotic, salt, and most importantly alkaline stress. The factor recognizes sequences on DNA and promotes the transcription of multiple genes.
In the non-stressed conditions, the activity of the SigmaW factor is inhibited by anti-sigma RsiW. Anti-sigma RsiW is a transmembrane protein that has cytoplasmic regions that tightly bind to and inhibit SigmaW. In conditions of stress, the transmembrane proteases cleave the transmembrane segment of RsiW, and ClpXP cleaves the regions of RsiW that are bound to SigmaW. This activates SigmaW and promotes the transcription of stress genes.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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