Part:BBa_K3428000
UV RESISTANCE LOCUS 8 (UVR8 )
UV RESISTANCE LOCUS 8 (UVR8) is a photoreceptor derived from Arabidopsis thaliana that is able to perceive light in the 280-315nm range. UVR8 plays an important role in photomorphogenesis and the UV-B hypersensitivity response in plants. In the absence of UV-B light, UVR8 exists as a homodimer. However, exposure to UV-B light triggers the monomerization of UVR8. UVR8 does not employ an exogenous chromophore and instead uses intrinsic tryptophan residues, specifically Trp-285 and Trp-233, as chromophores. Upon monomerization, C-terminal and N-terminal tails are released from the core of UVR8. The N-terminal tail of UVR8 contains a NLS responsible for its recruitment to the nucleus upon UV-B irradiation. The C-terminal tail (C27) facilitates interactions between UVR8 and its binding partner, COP1. These two proteins rapidly accumulate in the nucleus where they can regulate the expression of genes that provide UV-B protection.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12INCOMPATIBLE WITH RFC[12]Illegal NheI site found at 70
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000INCOMPATIBLE WITH RFC[1000]Illegal SapI site found at 85
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