Part:BBa_K2760002
gp130: (soluble human gp130, transducer for IL-6 complex)
This gene codes for the soluble human IL-6 transducer signaling glycoprotein 130, which is the beta chain of the IL-6 receptor complex. When gp80 and gp130 join that a high affinity complex for IL-6 is formed, thus binding with IL-6 occurs [1]. Studies have shown that this soluble form of gp130 is an inhibitor to trans-signaling events in the human body, via binding with the dimer of IL-6 and soluble gp80 (receptor, which circulates in the extracellular media [1]. This piece is meant to be used in a system to antagonically reduce trans-signaling. The inhibition of trans-signaling with novel drugs have been previously proposed to treat depressive patients [2], thus this piece was used for the design of Lactobachill (iGEM18_TecMonterrey_GDL), a proposed psychobiotic to be used as an adjoint in the treatment and prevention of depression.
Interleukin 6 (IL-6) is a multifunctional but majorly a proinflammatory cytokine within the IL-6 family. IL-6 signalization occurs via glycoprotein 130 (gp130, beta chain, of 130kDa) and the membrane-bound or soluble IL-6 receptor (gp80, alpha chain, of 80kDa), these piece is meant to unite with gp80, to form the high affinity complex in order to bind with IL-6 [3].
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 798
Illegal BamHI site found at 12 - 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000INCOMPATIBLE WITH RFC[1000]Illegal BsaI.rc site found at 400
Illegal SapI.rc site found at 417
Illegal SapI.rc site found at 637
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