Part:BBa_K2689001
Syntaxin1A
Syntaxins are nervous-specific integral membrane proteins involved in membrane fusion. They possess a C-terminal transmembrane domain, a SNARE domain and an N-terminal regulatory domain. Syntaxin-1A is involved in ion channel regulation and synaptic exocytosis. It interacts with SNAP25 and Synaptobrevin-2 to form the SNARE complex. This complex formation brings vesicle membrane and cell membrane into close proximity, which leads to merging of both membranes. In neuronal cells, synaptic vesicles store neurotransmitters that are released upon stimulation of the cell. This exocytosis process is, among other things, is regulated by Syntaxin1a.
Syntaxin-1A is a known substrate of botulinum neurotoxin C, a protein with metalloprotease activity which prevents the exocytosis of neurotransmitters into the neuromuscular junction. Consequently, this leads to flaccid paralysis symptoms of the illness botulism.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BamHI site found at 341
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000INCOMPATIBLE WITH RFC[1000]Illegal BsaI.rc site found at 77
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