Protein_Domain

Part:BBa_K2619008

Designed by: Peng Chai   Group: iGEM18_XJTLU-CHINA   (2018-09-10)


Connexin43

Connexin43 is a transmembrane protein that oligomerizes to form hexameric channels, called hemichannels, which is able to modulate the interaction and transfer of information between exosomes and acceptor cells. It was discovered that when the hemichannels in exosomes docking with hemichannels in the cell membrane, mRNA may be more likely to be transfered into cell cytoplasma from exosomes through a fusion event. The XJTLU-CHINA 2018 use this part to transfer our cargo mRNA into nerve cells.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI site found at 782
    Illegal SapI.rc site found at 418


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Categories
Parameters
None