Part:BBa_K2372004
Very potent, broad-spectrum beta-lactamase
SHV-1 is an enzyme of the β-lactamase family typically found in Klebsiella pneumoniae. This enzyme mediates resistance against a wide spectrum of ꞵ-lactams and is responsible for up to 20% of the plasmid-mediated ampicillin resistance in this species. SHV-1 belongs to a group of so called extended-spectrum β-lactamases (ESBLs) which are known for inhibiting antibiotics by hydrolysis. Most problematic is the fact, that ESBLs are encoded by genes that can be exchanged between bacteria.
| SHV-1 | |
|---|---|
| Function | Wide range β-Lactamase(Resistance factor) |
| Use in | Prokaryotic cells |
| RFC standard | RFC 10 |
| Backbone | pSB1C3 |
| Organism | Klebsiella pneumoniae |
| Source | IDT (DNA synthesis) |
| Submitted by | Tuebingen 2017 |
References:
Shaikh, S., Fatima, J., Shakil, S., Rizvi, S. M., & Kamal, M. A. (2015). Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment. Saudi J Biol Sci, 22(1), 90-101. doi:10.1016/j.sjbs.2014.08.002
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12INCOMPATIBLE WITH RFC[12]Illegal NotI site found at 146
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal NgoMIV site found at 663
- 1000COMPATIBLE WITH RFC[1000]
| None |