Coding

Part:BBa_K2358002

Designed by: Peiyue Zhuang   Group: iGEM17_JNFLS   (2017-10-25)


TAT stands for "Trans-Activator of Transcription", serving as a trans-activating factor in HIV-1.

TAT is a protein that is encoded by the tat gene in HIV-1. TAT is a regulatory protein that drastically enhances the efficiency of viral transcription. TAT vastly increases the level of transcription of the HIV dsDNA. TAT also appears to play a more direct role in the HIV disease process. The protein is released by infected cells in culture, and is found in the blood of HIV-1 infected patients. It also can be absorbed by cells that are not infected with HIV, and can act directly as a toxin producing cell death via apoptosis in uninfected bystander cells.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BamHI site found at 3
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None