Part:BBa_K1841005

peptide yy (PYY)

Peptide YY is a gastrointestinal (GI) hormone that can restrain our appetite. Because this short peptide’s the terminal amino acids in each end are tyrosine (Y), it is named peptide YY (PYY). There are two main endogenous forms: PYY1–36 and PYY3–36. Both are stable without the need of disulfide bonds. The latter is produced by the action of the enzyme dipeptidyl peptidase-IV (DPP-IV). The conformational change of PYY3-36 alleviates its binding affinity to the NPY Y2 receptor (Y2R). Peptide YY plays an important role in controlling appetite. After our intestine absorbs micromolecule nutrient, the L-type endocrine cell (L cell) will secret PYY to blood. Along the blood flow, PYY could enter the arcuate nucleus in hypothalamus and then bind with Y2R. The binding decreases our appetite and inhibits eating.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]