Part:BBa_K1772001
Manganese peroxidase is an enzyme that is capable of oxidizing of Mn^2+ ions into Mn^3+ ions by using an irreversible redox reaction with the aid of fungal chelators such as oxalic acid . This enzyme is specifically used by Heterobasidion irregulare TC 32-1, a variety of white rot fungus, to break down any wooden material in it’s path. Although the enzyme itself is not directly linked to lignin breakdown, the Mn^3+ ions that it creates are then able to attack and oxidize organic molecules such as phenolic substrates or several lignin compounds. These lignin compounds are broken down into free radicals which quickly degrade due to their molecular instability. Note: Calcium ions and heme-B are involved with the enzyme’s mechanism.
2 Mn(II) + 2 H+ + H2O2 → 2 Mn(III) + 2 H2O
Sources:
Basic Format: Acalgaro. (2013). Mangenese Peroxidase Mechanism [PNG]. Retrieved from [1]
![[1]](https://commons.wikimedia.org/wiki/File:Manganese_peroxidase_mechanism.png){kind=link}
Hofrichter, M. (2002). Review: Lignin conversion by manganese peroxidase (MnP). Retrieved September 16, 2015, from [http://www.sciencedirect.com/science/article/pii/S0141022901005282]
Manganese peroxidase (CAS 114995-15-2). (2007). Retrieved September 16, 2015, from [http://www.scbt.com/datasheet-211772-manganese-peroxidase.html]
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