Part:BBa_K1647019
Cap-AAP2, a improved antimicrobial peptide which can kill the S.mutans selectively and have changeab
The CAP is a short peptide derived from the competence stimulation peptide (CSP) which can bind to the receptors on the membrane of the Streptococcus mutans selectively. APP2, a antimicrobial peptide, can achieve high activity exclusively at low environmental pH to target bacterial species like S. mutans that produce acid and thrive under the low pH conditions detrimental for tooth integrity. However, at pH 7.5, it has no effect on cell viability. The part is a new improved peptide, based on the fusion of a S. mutans-specific targeting peptide domain with a special antimicrobial peptide domain which has strong antibacterial ability at acid environment, however, which can restrain or even kill the S.mutans specifically. The fused peptide also have weak effect on the other bacteria when the pH value is equal to or more than 7.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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