Part:BBa_K1228002

Rabies virus strain ERA glycoprotein coding sequence

The RNA genome of the virus encodes five genes whose order is highly conserved. These genes code for nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G) and the viral RNA polymerase (L).The complete genome sequences range from 11,615 to 11,966 nt in length. Because of containing the neutralizing epitopes which are the targets of vaccine-induced immunity, the glycoprotein can stimulate the organism to produce antibody against Rabies.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  INCOMPATIBLE WITH RFC[21]

  Illegal XhoI site found at 510
  
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  INCOMPATIBLE WITH RFC[1000]

  Illegal BsaI site found at 1338
  Illegal BsaI site found at 1357
  Illegal BsaI.rc site found at 1564
  

Acknowledge

Associate professor MinCui provided the glycoprotein coding gene for us. We are grateful to her. The following is her homepage. http://my.hzau.edu.cn/Article/ShowArticle.asp?ArticleID=1831

References

1. Morimoto K, Hooper DC, Spitsin S, et al. Pathogenicity of different rabies virus variants inversely correlates with apoptosis and rabies virus glycoprotein expression in infected primary neuron cultures. J Virol, 1999; 73, 510‐8.

2. http://en.wikipedia.org/wiki/Rabies_virus