Part:BBa_K1162008
OH-CATH (3-34) antimicrobial peptide from the King Cobra (Ophiophagus hannah)
OH-CATH(3-34) is an antimicrobial peptide isolated and characterized from the king cobra (Ophiophagus hannah)(Zhao et al 2008). A member of the cathelicidin family, OH-CATH Cathelicidins in general have been well characterized and are known to have a diverse C-terminal antimicrobial domain connected to a conserved cathelin-like N-terminal domain (Nizet et al 2003). Specifically, OH-CATH has been studied for its toxicity against a wide range of gram negative and gram positive bacteria. OH-CATH has also been characterized for its potent activity against multi-drug resistant bacterial strains including MRSA (Li et al 2012). Further studies by (Zhang et al 2010) have shown that removing the first few amino acid residues of the peptide dramatically reduced the hemolytic activity while having only minute effects on antimicrobial properties. This attribute would be highly desirable in any usage that would interact with humans and helped to determine our choice our peptides. The combination of high bacterial toxicity with low hemolytic activity justify more testing into the precise mechanisms of OH-CATH and its ability to be used as a scaffold for other antibiotic purposes.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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