Coding

Part:BBa_I10501

Designed by: Andre' Green II   Group: BE.109 2006 BE.109 Instructors   (2006-05-16)


Calcium-sensing receptor protein

CaR has been shown to be crucial in a myriad of metabolic pathways, reflecting the importance of Ca2+ in many different processes. Most recently, CaR has been shown to be expressed on the surface of human oocytes and aortic endothelial cells.

The following summary can be found at NCBI: "The calcium-sensing receptor (CASR) functions as a sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, whereas mutations that activate CASR are the cause of autosomal dominant hypocalcemia."

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 147
    Illegal BglII site found at 822
    Illegal BglII site found at 872
    Illegal BglII site found at 2567
    Illegal BglII site found at 3069
    Illegal BamHI site found at 2719
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal NgoMIV site found at 2043
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI.rc site found at 1213
    Illegal BsaI.rc site found at 3113
    Illegal SapI site found at 474
    Illegal SapI site found at 1326


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Categories
Parameters
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