Protein domains/Overview

Protein tags and modifiers are short peptide sequences cloned in frame with protein coding sequences that change the protein's behavior.

Protein tags and modifiers might

• change the protein's location (localization signals)
• enable it to be readily purified (affinity tags)
• fuse two protein domains together (linkers)
• alter the protein's degradation rate (degradation tags)
• target the protein for cleavage (cleavage sites)

Protein tags may include a start codon or a stop codon, but not both, since they are intended to be assembled in frame with protein coding sequences.

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Protein coding sequences (?): Protein coding sequences encode the amino acid sequence of a particular protein. Note that some protein coding sequences only encode a protein domain or half a protein. Others encode a full-length protein from start codon to stop codon.