Coding

Part:BBa_M1437

Designed by: Trevor Russell Ballard   Group: UtahState_BE5930_-_S11   (2013-04-25)


Enteropeptidase from Homo sapiens optimized for E. coli

Enteropeptidase is an enzyme secreted in the small intestine necessary for digestion in humans. It is necessary for trypsin activation and acts as a serine protease.

Information contributed by City of London UK (2021)

Part information is collated here to help future users of the BioBrick registry.

Metadata:

  • Group: City of London UK 2021
  • Author: Lucas Ng
  • Summary: Added information collated from existing scientific studies

Enteropeptidase converts the zymogen trypsinogen to trypsin by selectively cleaving the 6-Lys-|-Ile-7 bond. This in turn activates other pancreatic proteolytic proenzymes such as chymotrypsinogen, procarboxypeptidases, and proelastases [1].

References

  1. ↑ “TMPRSS15 - Enteropeptidase Precursor - Homo Sapiens (Human) - TMPRSS15 Gene & Protein.” n.d. Www.uniprot.org. Accessed July 26, 2021. https://www.uniprot.org/uniprot/P98073.
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Categories
//cds/enzyme/protease
//chassis/eukaryote/human
Parameters
None