Generator
Part:BBa_K814003
Designed by: Nolan Kennedy, Michelle Goettge, Grayson Wawrzyn Group: iGEM12_Minnesota (2012-10-03)
Revision as of 22:57, 13 October 2012 by Swan1531 (Talk | contribs) (New page: Our research has focused on two novel biosynthetic pathways found in two distinct algal species. A pathway ending in the production of two UV-protective compounds, shinorine and mycosporin...)
Our research has focused on two novel biosynthetic pathways found in two distinct algal species. A pathway ending in the production of two UV-protective compounds, shinorine and mycosporine-glycine, was cloned from Anabaena varibalis. DHQS catalyzes the first step in the pathway, converting sedoheptulose-7-phosphate into dehydroquinate. Dehydroquinate-O-methyltransferase (O-MT) then generates 4-deoxygadusol, which is converted to mycosprine-glycine by ATP-grasp (ATPG).
This composite part contains a protein generator for NRPS.
Figure 1. Shinorine biosynthetic pathway including the NRPS generator stacked in a BioBrick conformation.
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