Part:BBa_K4049056
Anti Tbx2 siRNA
Tbx2 is a member of the T-box family of transcription factors that are crucial in embryonic development. Tbx2 is involved in several developmental processes such as coordinating cell fate, patterning and morphogenesis of a wide range of tissues and organs including limbs, kidneys, lungs, mammary glands, heart, and craniofacial structures. It has been seen that, Tbx2 is overexpressed in several cancers including melanoma, small cell lung carcinoma, breast, pancreatic, liver, and could suppress senescence, a cellular process, which serves as a barrier to cancer development. Anti Tbx2 siRNA targets Tbx2 gene and regulates the expression of gene through mechanism of RNA- interferece. The siRNA interferes with Tbx2 mRNA as part of multiprotein RISC complex and provides mRNA degradation, preventing translation. It has potential applications as radioprotective molecule in radiotherapy, space flights and other cases of exposure to ionizing radiation on humans and gene therapy of cancers.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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