RNA

Part:BBa_K4049011

Designed by: Bertha Yliana Valdez Fernandez   Group: iGEM21_MEPhI   (2021-10-21)


Anti PDCD11 siRNA

PDCD11 is a NF-kappa-B binding protein that colocalizes with U3 RNA in the nucleolus and is required for rRNA maturation and generation of 18S rRNA. Anti PDCD11 siRNA targets PDCD11 gene and regulates the expression of gene through mechanism of RNA- interferece. The siRNA interferes with PDCD11 mRNA as part of multiprotein RISC complex and provides mRNA degradation, preventing translation. It has potential applications as radioprotective molecule in radiotherapy, space flights and other cases of exposure to ionizing radiation on humans.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None